首页|筋骨消痛散联合富血小板血浆对膝关节骨性关节炎患者的临床疗效

筋骨消痛散联合富血小板血浆对膝关节骨性关节炎患者的临床疗效

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目的 考察筋骨消痛散联合富血小板血浆对膝关节骨性关节炎患者的临床疗效.方法 96 例患者随机分为对照组和观察组,每组 48 例,对照组给予富血小板血浆,观察组在对照组基础上加用筋骨消痛散,疗程 8 周.检测临床疗效、IL-17、SDF-1、TLR4、GSH-Px、NO、ox-LDL、WOMAC评分、中医证候评分、AIMS2-SF评分变化.结果 观察组总有效率高于对照组(P<0.05).治疗后,2 组IL-17、SDF-1、TLR4、NO、ox-LDL、WOMAC评分、中医证候评分降低(P<0.05),GSH-Px、AIMS2-SF评分升高(P<0.05),以观察组更明显(P<0.05).结论 筋骨消痛散联合富血小板血浆可降低膝关节骨性关节患者IL-17、SDF-1、TLR4 水平,抑制机体炎症,改善氧化应激指标,缓解疼痛,提升临床疗效和生活质量.
Clinical effects of Jingu Xiaotong Powder combined with platelet-rich plasma on patients with knee osteoarthritis
AIM To investigate the clinical effects of Jingu Xiaotong Powder combined with platelet-rich plasma on patients with knee osteoarthritis.METHODS Ninety-six patients were randomly assigned into control group(48 cases)for 8-week administration of platelet-rich plasma,and observation group(48 cases)for 8-week administration of both Jingu Xiaotong Powder and platelet-rich plasma.The changes in clinical effects,IL-17,SDF-1,TLR4,GSH-Px,NO,ox-LDL,WOMAC scores,TCM syndrome score,AIM2-SF score were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05).After the treatment,the two groups displayed decreased IL-17,SDF-1,TLR4,NO,ox-LDL,WOMAC scores,TCM syndrome score(P<0.05),and increased GSH-Px,AIM2-SF score(P<0.05),especially for the observation group(P<0.05).CONCLUSION For the patients with knee osteoarthritis,Jingu Xiaotong Powder combined with platelet-rich plasma can reduce IL-17,SDF-1,TLR4 levels,inhibit body inflammation,improve oxidative stress indices,alleviate pain,and enhance clinical efficacy and life quality.

Jingu Xiaotong Powderplatelet-rich plasmaknee osteoarthritis

张睿昕、王勤俭、姜幸福、李泊泊、徐冬康

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河南省中医院/河南中医药大学第二附属医院骨病二科, 河南 郑州 450002

筋骨消痛散 富血小板血浆 膝关节骨性关节炎

河南省中医药科学研究专项课题河南省中医药科学研究专项课题

2019JDZX05520-21ZY3017

2024

中成药
国家食品药品监督管理局,信息中心中成药信息站,上海中药行业协会

中成药

CSTPCD北大核心
影响因子:1.217
ISSN:1001-1528
年,卷(期):2024.46(2)
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