首页|雪上一枝蒿生物碱可溶性微针制备

雪上一枝蒿生物碱可溶性微针制备

扫码查看
目的 制备雪上一枝蒿生物碱可溶性微针.方法 离心注模法制备可溶性微针.在单因素试验基础上,以硫酸软骨素用量、PVP K120 用量、40%乙醇用量为影响因素,刺孔率为评价指标,Box-Behnken响应面法优化处方,考察形态、穿刺性能、含药量、体外透皮性能.结果 最优处方为硫酸软骨素用量 123 mg,PVP K120 用量 298 mg,40%乙醇用量 2.4 mL,刺孔率为 98.3%.可溶性微针为黄色正方形贴片,针体呈圆锥形,可刺穿铝箔和大鼠皮肤,含药量为(0.94±0.025)mg.可溶性微针组 24h内累积渗透率为 91.4%,明显高于凝胶膏剂组,渗透符合Higuchi方程.结论 雪上一枝蒿可溶性微针机械强度较好,可实现药物的有效经皮递送.
Preparation of soluble microneedles of Aconitum brachypodum alkaloids
AIM To prepare the soluble microneedles of Aconitum brachypodum Diels alkaloids.METHODS Centrifugal molding method was adopted in the preparation of soluble microneedles.With chondroitin sulfate consumption,PVP K120 consumption and 40%ethanol consumption as influencing factors,piercing rate as an evaluation index,the formulation was optimized by Box-Behnken response surface method,after which the morphology,piercing performance,drug content and in vitro transdermal performance were investigated.RESULTS The optimal formulation was determined to be 123 mg for chondroitin sulfate consumption,298 mg for PVP K120 consumption,and 2.4 mL for 40%ethanol consumption,the piercing rate was 98.3%.The soluble microneedles were yellow and square patch with conoid needle,which could pierce aluminum foil and rat skin,along with the drug content of(0.94±0.025)mg.The soluble microneedle group demonstrated the accumulative permeability rate of 91.4%within 24 h,which was higher than that in the gel ointment group,and the permeability accorded with Higuchi equation.CONCLUSION The soluble microneedles of A.brachypodum alkaloids exhibit good mechanical strength,which can achieve effective transdermal delivery of drugs.

Aconitum brachypodum Dielsalkaloidssoluble microneedlespreparation processcentrifugal molding method

陈瑶、邓铋莉、万静、董娜娜、陈晓兰、张永萍

展开 >

贵州中医药大学,贵州 贵阳 550025

毕节医学高等专科学校,贵州 毕节 553302

雪上一枝蒿 生物碱 可溶性微针 制备工艺 离心注模法

贵州省国内一流学科建设项目贵州省药物新剂型新工艺科技创新人才团队项目贵州中医药大学大学生创新创业训练计划

GNYL[2017]008号黔科合平台人才[2017]5655号贵中医大创合字[2020]9号

2024

中成药
国家食品药品监督管理局,信息中心中成药信息站,上海中药行业协会

中成药

CSTPCD北大核心
影响因子:1.217
ISSN:1001-1528
年,卷(期):2024.46(3)
  • 23