摘要
目的 探讨补肺化痰定喘汤对肺肾亏虚型慢性阻塞性肺疾病急性加重期患者的临床疗效.方法 138 例患者随机分为对照组和观察组,每组 69 例,对照组给予常规治疗,观察组在对照组基础上加用补肺化痰定喘汤,疗程 4 周.检测临床疗效、MMP-2、HIF-1α、TGF-β1、Gal-3、IL-6、肺功能指标(FVC、PEF、FEV1/FVC)、6 min 步行距离、CAT评分、中医证候评分变化.结果 观察组总有效率高于对照组(P＜0.05).治疗后,2 组MMP-2、HIF-1α、TGF-β1、IL-6、Gal-3、CAT评分、中医证候评分降低(P＜0.05),肺功能指标(FVC除外)升高(P＜0.05),6 min步行距离延长(P＜0.05),以观察组更明显(P＜0.05).结论 补肺化痰定喘汤可减轻肺肾亏虚型慢性阻塞性肺疾病急性加重期患者炎症反应,改善机体缺氧状态,调节肺功能,防止气道组织重塑,促进病情恢复,提高临床疗效.
Abstract
AIM To explore the clinical effects of Bufei Huatan Dingchuan Decoction on patients with acute exacerbation of chronic obstructive pulmonary disease of Lung-Kidney Deficiency Pattern.METHODS One hundred and thirty-eight patients were randomly assigned into control group(69 cases)for 4-week intervention of conventional treatment,and observation group(69 cases)for 4-week intervention of both Bufei Huatan Dingchuan Decoction and conventional treatment.The changes in clinical effects,MMP-2,HIF-1α,TGF-β1,Gal-3,IL-6,pulmonary function indices(FVC,PEF,FEV1/FVC),6-minute walk distance,CAT score and TCM syndrome score were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P＜0.05).After the treatment,the two groups displayed decreased MMP-2,HIF-1α,TGF-β1,IL-6,Gal-3,CAT score,TCM syndrome score(P＜0.05),increased function indices(except for FVC)(P＜0.05),and prolonged 6-minute walk distance(P＜0.05),especially for the observation group(P＜0.05).CONCLUSION For the patients of Lung-Kidney Deficiency Pattern,Bufei Huatan Dingchuan Decoction can alleviate inflammatory reactions,improve body hypoxia state,regulate lung functions,prevent airway tissue remodeling,promote disease recovery,and enhance clinical effects.
维普
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