摘要
目的 考察丹篓片联合阿托伐他汀钙片对痰瘀互结证稳定性心绞痛患者的临床疗效.方法 80 例患者随机分为对照组和观察组,每组 40 例,对照组给予阿托伐他汀钙片,观察组在对照组基础上加用丹篓片,疗程 8 周.检测临床疗效、中医证候评分、血管内皮功能指标(NO、VEGF、ET-1)、血脂相关指标(TC、TG、HDL-C、LDL-C、脂蛋白a、ApoB/A1)、24 h动态心电图指标(缺血发作次数、最长持续时间、心脏缺血总负荷)、SAQ评分、安全性指标(AST、ALT、Scr、BUN)变化.结果 观察组总有效率高于对照组(P<0.05).治疗后,2 组中医证候评分、ET-1、TC、TG、LDL-C、脂蛋白a、ApoB/A1、24 h动态心电图指标降低(P<0.05),NO、VEGF、HDL-C、SAQ评分升高(P<0.05),以观察组更明显(P<0.05).2 组安全性指标比较,差异无统计学意义(P>0.05).结论 丹篓片联合阿托伐他汀钙片可安全有效地改善痰瘀互结证稳定性心绞痛患者心肌缺血程度、临床症状,调节血脂,减轻血管内皮损伤.
Abstract
AIM To investigate the clinical effects of Danlou Tablets combined with Atorvastatin Calcium Tablets on patients with stable angina pectoris of Intermingled Phlegm and Blood Stasis Pattern.METHODS Eighty patients were randomly assigned into the control group(40 cases)for 8-week administration of Atorvastatin Calcium Tablets,and observation group(40 cases)for 8-week administration of both Danlou Tablets and Atorvastatin Calcium Tablets.The changes in clinical efficacy,TCM syndrome scores,vascular endothelial function indices(NO,VEGF,ET-1),lipid-related indices(TC,TG,HDL-C,LDL-C,lipoprotein a,ApoB/A1),24 h dynamic electrocardiogram indices(ischemic attack number,longest duration,total cardiac ischemia load),SAQ score and safety indices(AST,ALT,Scr,BUN)were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05).After the treatment,the two groups displayed decreased TCM syndrome scores,ET-1,TC,TG,LDL-C,lipoprotein a,ApoB/A1,24 h dynamic electrocardiogram indices(P<0.05),and increased NO,VEGF,HDL-C,SAQ score(P<0.05),especially for the observation group(P<0.05).CONCLUSION For the patients with stable angina pectoris due to Binding of Phlegm and Blood Stasis,Danlou Tablets combined with Atorvastatin Calcium Tablets can safely and effectively improve myocardial ischemia degree and clinical symptoms,regulate blood lipids,and alleviate vascular endothelial damage.
基金项目
上海市科委"扬帆计划"项目(20YF1437000)
浦东新区国家中医药发展综合改革试验区叶玉妹浦东中医名家工作室项目(PDZY-2021-1005)
上海中医药大学"杏林百人"计划(上中医人字[2020]23号)
国家科技期刊平台
NSTL
维普
万方数据