Clinical effects of Shenling Yiyi Sanqi Formula combined with enema of Zhixue Shengji Decoction on patients with ulcerative colitis due to Spleen Deficiency with Dampness-Heat
AIM To investigate the clinical effects of Shenling Yiyi Sanqi Formula combined with enema of Zhixue Shengji Decoction on patients with ulcerative colitis due to Spleen Deficiency with Damp-Heat.METHODS One hundred and fourteen patients were randomly assigned into control group(57 cases)for 4-week intervention of enema of Zhixue Shengji Decoction,and observation group(57 cases)for 4-week intervention of both Shenling Yiyi Sanqi Formula and enema of Zhixue Shengji Decoction.The changes in clinical effects,TCM syndrome scores,Baron endoscopic score,modified Mayo score,VAS score,intestinal flora(Enterococcus,Lactobacillus,Enterobacterium,Bifidobacterium),correlation factors(FCP,ESR,IL-10,TNF-α,TLR4,PGE2),intestinal barrier function factors(L/M,DAO,D-lactic acid)and safety indices were detected.RESULTS The observation group demonstrated higher complete remission rate and total effective rate than the control group(P＜0.05).After the treatment,the two groups displayed decreased TCM syndrome scores,Baron endoscopic score,modified Mayo score,VAS score,FCP,ESR,TNF-α,TLR4,PGE2,intestinal barrier function factors(P＜0.05),increased IL-10(P＜0.05),reduced Enterococcus,Enterobacterium,and enhanced Lactobacillus,Bifidobacterium(P＜0.05),especially for the observation group(except for Enterococcus)(P＜0.05).No obvious adverse reactions were observable in the two groups.CONCLUSION For the patients with ulcerative colitis due to Spleen Deficiency with Dampness-Heat,Shenling Yiyi Sanqi Formula combined with enema of Zhixue Shengji Decoction can safely and effectively regulate intestinal flora,improve intestinal barrier function,and enhance analgesic,anti-inflammatory effects.
Shenling Yiyi Sanqi FormulaZhixue Shengji Decoctionenemaulcerative colitisSpleen Deficiency with Dampness-Heat
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维普
