首页|参芪桃花四物汤合复遂汤联合针刺对气虚血瘀证缺血性脑梗死恢复期痉挛性瘫痪患者的临床疗效

参芪桃花四物汤合复遂汤联合针刺对气虚血瘀证缺血性脑梗死恢复期痉挛性瘫痪患者的临床疗效

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目的 探讨参芪桃花四物汤合复遂汤联合针刺对气虚血瘀证缺血性脑梗死恢复期痉挛性瘫痪患者的临床疗效.方法 92例患者随机分为对照组和观察组,每组46例,2组采用常规治疗,同时对照组给予针刺,观察组在对照组基础上加用参芪桃花四物汤合复遂汤,疗程4周.检测临床疗效、中医证候评分、血清学指标(Glu、GABA、Glu/GABA、Gly、HCY、ASP)、神经功能指标(BDNF、NGF、NT-3)、NIHSS 评分、FMA 评分、MAS 评分、Barthel 评分、表面肌电信号(Hmax、Mmax、Hmax/Mmax)、不良反应发生率变化.结果 观察组总有效率高于对照组(P<0.05).治疗后,2组GABA、Gly、神经功能指标、FMA评分、Barthel评分升高(P<0.05),中医证候评分、Glu、Glu/GABA、HCY、ASP、NIHSS评分、MAS评分、表面肌电信号降低(P<0.05),以观察组更明显(P<0.05).2组不良反应发生率比较,差异无统计学意义(P>0.05).结论 参芪桃花四物汤合复遂汤联合针刺可安全有效地改善气虚血瘀证缺血性脑梗死恢复期痉挛性瘫痪患者神经功能、运动功能、生活质量,降低中医证候评分、痉挛程度.
Clinical effects of Shenqi Taohua Siwu Decoction plus Fusui Decoction combined with acupuncture on patients with post-ischemic stroke spastic paralysis due to Qi Deficiency and Blood Stasis
AIM To explore the clinical effects of Shenqi Taohua Siwu Decoction plus Fusui Decoction combined with acupuncture on patients with post-ischemic stroke spastic paralysis due to Qi Deficiency and Blood Stasis.METHODS Ninety-two patients were randomly assigned into control group(46 cases)for 4-week intervention of both acupuncture and conventional treatment,and observation group(46 cases)for 4-week intervention of Shenqi Taohua Siwu Decoction,Fusui Decoction,acupuncture and conventional treatment.The changes in clinical effects,TCM syndrome scores,serological indices(Glu,GABA,Glu/GABA,Gly,HCY,ASP),nervous function indices(BDNF,NGF,NT-3),NIHSS score,FMA score,MAS score,Barthel score,surface electromyography signals(Hmax,Mmax,Hmax/Mmax)and incidence of adverse reactions were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05).After the treatment,the two groups demonstrated increased GABA,Gly,nervous function indices,FMA score,Barthel score(P<0.05),and decreased TCM syndrome scores,Glu,Glu/GABA,HCY,ASP,NIHSS score,MAS score,surface electromyography signals(P<0.05),especially for the observation group(P<0.05).No significant difference in incidence of adverse reactions was found between the two groups(P>0.05).CONCLUSION For the patients with post-ischemic stroke spastic paralysis due to Qi Deficiency and Blood Stasis,Shenqi Taohua Siwu Decoction plus Fusui Decoction combined with acupuncture can safely and effectively improve nerve functions,motor functions,life quality,and reduce TCM syndrome scores,spasticity degree.

Shenqi Taohua Siwu DecoctionFusui Decoctionacupunctureconventional treatmentspastic paralysispost-ischemic strokerecovery stageQi Deficiency and Blood Stasis

王琨、任静、于文琪、徐大伟、孙慧

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青岛大学附属青岛市海慈医院(青岛市中医医院)针推科,山东青岛 266000

青岛大学附属青岛市海慈医院(青岛市中医医院)呼吸与危重症医学科肺病中心,山东青岛 266000

平度市第二人民医院神经内科,山东青岛 266731

参芪桃花四物汤 复遂汤 针刺 常规治疗 痉挛性瘫痪 缺血性脑梗死 恢复期 气虚血瘀

山东省中医药科技项目

2021Q055

2024

中成药
国家食品药品监督管理局,信息中心中成药信息站,上海中药行业协会

中成药

CSTPCD北大核心
影响因子:1.217
ISSN:1001-1528
年,卷(期):2024.46(6)
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