Clinical effects of Lingze Jiangzhi Decoction combined with Polyene Phosphatidylcholine Capsules on patients with non-alcoholic fatty liver disease
AIM To explore the clinical effects of Lingze Jiangzhi Decoction combined with Polyene Phosphatidylcholine Capsules on patients with non-alcoholic fatty liver disease.METHODS Eighty patients were randomly assigned into control group(40 cases)for 3-month administration of Polyene Phosphatidylcholine Capsules,and observation group(40 cases)for 3-month administration of both Lingze Jiangzhi Decoction and Polyene Phosphatidylcholine Capsules.The changes in clinical effects,blood lipid indices(TC,HDL-C,LDL-C,TG),blood glucose indices(HbA1c,FPG),LPS,oxidative stress indices(T-AOC,SOD,NO),insulin sensitivity indices(GLUT4,IRS1,IRS2),liver function indices(ALT,AST),liver injury indices(γ-2GT,TGF-β,LEP,nuclear factor κB)and TCM symptom scores were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P＜0.05).After the treatment,the two groups displayed decreased TC,LDL-C,TG,blood glucose indices,LPS,NO,liver function indices,liver injury indices,TCM symptom scores(P＜0.05),and decreased HDL-C,T-AOC,SOD,insulin sensitivity indices(P＜0.05),especially for the observation group(P＜0.05).CONCLUSION For the patients with non-alcoholic fatty liver disease,Lingze Jiangzhi Decoction combined with Polyene Phosphatidylcholine Capsules can improve glucose and lipid metabolism,insulin sensitivity,liver functions,inhibit inflammation,reduce oxidative stress injury,liver injury,and enhance clinical efficacy.
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