摘要
目的 探讨苓泽降脂汤联合多烯磷脂酰胆碱胶囊对非酒精性脂肪性肝病患者的临床疗效.方法 80 例患者随机分为对照组和观察组,每组 40 例,对照组给予多烯磷脂酰胆碱胶囊,观察组在对照组基础上加用苓泽降脂汤,疗程 3 个月.检测临床疗效、血脂指标(TC、HDL-C、LDL-C、TG)、血糖指标(HbA1c、FPG)、LPS、氧化应激指标(T-AOC、SOD、NO)、胰岛素敏感性指标(GLUT4、IRS1、IRS2)、肝功能指标(ALT、AST)、肝损伤指标(γ-2GT、TGF-β、LEP、核因子κB)、中医证候评分变化.结果 观察组总有效率高于对照组(P＜0.05).治疗后,2 组TC、LDL-C、TG、血糖指标、LPS、NO、肝功能指标、肝损伤指标、中医证候评分降低(P＜0.05),HDL-C、T-AOC、SOD、胰岛素敏感性指标升高(P＜0.05),以观察组更明显(P＜0.05).结论 苓泽降脂汤联合多烯磷脂酰胆碱胶囊可改善非酒精性脂肪性肝病患者糖脂代谢、胰岛素敏感性和肝功能,抑制炎症,减少氧化应激损伤和肝损伤,提升临床疗效.
Abstract
AIM To explore the clinical effects of Lingze Jiangzhi Decoction combined with Polyene Phosphatidylcholine Capsules on patients with non-alcoholic fatty liver disease.METHODS Eighty patients were randomly assigned into control group(40 cases)for 3-month administration of Polyene Phosphatidylcholine Capsules,and observation group(40 cases)for 3-month administration of both Lingze Jiangzhi Decoction and Polyene Phosphatidylcholine Capsules.The changes in clinical effects,blood lipid indices(TC,HDL-C,LDL-C,TG),blood glucose indices(HbA1c,FPG),LPS,oxidative stress indices(T-AOC,SOD,NO),insulin sensitivity indices(GLUT4,IRS1,IRS2),liver function indices(ALT,AST),liver injury indices(γ-2GT,TGF-β,LEP,nuclear factor κB)and TCM symptom scores were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P＜0.05).After the treatment,the two groups displayed decreased TC,LDL-C,TG,blood glucose indices,LPS,NO,liver function indices,liver injury indices,TCM symptom scores(P＜0.05),and decreased HDL-C,T-AOC,SOD,insulin sensitivity indices(P＜0.05),especially for the observation group(P＜0.05).CONCLUSION For the patients with non-alcoholic fatty liver disease,Lingze Jiangzhi Decoction combined with Polyene Phosphatidylcholine Capsules can improve glucose and lipid metabolism,insulin sensitivity,liver functions,inhibit inflammation,reduce oxidative stress injury,liver injury,and enhance clinical efficacy.
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