摘要
目的 探讨实炎方对湿热蕴肠型溃疡性结肠炎患者的临床疗效.方法 82 例患者随机分为对照组和观察组,每组 41 例,对照组给予美沙拉嗪肠溶片,观察组在对照组基础上加用实炎方,疗程 8 周.检测临床疗效、中医证候评分、炎症因子(白细胞介素-6、白细胞介素-22、白细胞介素-33)、肠黏膜屏障功能指标(二胺氧化酶、D-乳酸、内毒素)、肠道菌群(大肠杆菌、肠球菌、双歧杆菌、乳酸杆菌)、GQOLI-74 评分变化.结果 观察组总有效率高于对照组(P<0.05).治疗后,2 组中医证候评分、血清炎症因子、肠黏膜屏障功能指标降低(P<0.05),GQOLI-74 升高(P<0.05),肠球菌减少(P<0.05),双歧杆菌、乳酸杆菌增加(P<0.05),以观察组更明显(P<0.05).结论 实炎方可提高溃疡性结肠炎患者生活质量,临床疗效明显.
Abstract
AIM To explore the clinical effects of Shiyan Prescription on patients with ulcerative colitis due to Bowel Dampness-Heat Stagnation.METHODS Eighty-two patients were randomly assigned into control group(41 cases)for 8-week administration of Mesalazin Enteric-coated Tablets,and observation group(41 cases)for 8-week administration of both Shiyan Prescription and Enteric-coated Tablets.The changes in clinical effects,TCM syndrome scores,serum inflammatory factors(interleukin-6,interleukin-22,interleukin-33),intestinal mucosal barrier function indices(diamine oxidase,D-lactic acid,endotoxin),intestinal flora(Escherichia coli,Enterococcus,Bifidobacterium,Lactobacillus)and GQOLI-74 scores were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P＜0.05).After the treatment,the two groups displayed decreased TCM syndrome scores,serum inflammatory factors,intestinal mucosal barrier function indices(P＜0.05),increased GQOLI-74 scores(P＜0.05),reduced Enterococcus(P＜0.05),and enhanced Bifidobacterium,Lactobacillus(P＜0.05),especially for the observation group(P＜0.05).CONCLUSION For the patients with ulcerative colitis due to Bowel Dampness-Heat Stagnation,Shiyan Prescription can enhance life quality with obvious clinical effects.
基金项目
上海市临床重点专科 2019年评审项目(shslczdzk04302)
上海市卫生健康委员会科研课题(20204Y0180)
上海中医药大学附属曙光医院"四明临床研究专项"(SGKJLL-202006)
国家科技期刊平台
NSTL
万方数据