摘要
目的 考察通腑醒神汤联合腹针加温针灸对老年脑卒中后认知障碍患者的临床疗效.方法 98例患者随机分为对照组和观察组,每组49例,对照组给予腹针加温针灸,观察组在对照组基础上加用通腑醒神汤,疗程1个月.检测临床疗效、MoCA评分、NIHSS评分、SDSVD评分、ADL评分、神经递质(DA、5-HT、NE)、血液流变学指标(高切黏度、低切黏度、血浆黏度、红细胞压积)、血流动力学指标(平均血流速度、平均血流量、特征性阻抗、动态阻抗)、细胞凋亡指标(Bcl-2、Bax、Caspase3)变化.结果 观察组总有效率高于对照组(P<0.05).治疗后,2组MoCA评分、ADL评分、神经递质、平均血流速度、平均血流量、Bcl-2升高(P<0.05),NIHSS评分、SDSVD评分、血液流变学指标、特征性阻抗、动态阻抗、Bax、Caspase3降低(P<0.05),以观察组更明显(P<0.05).结论 通腑醒神汤联合腹针加温针灸可改善老年脑卒中后认知障碍患者认知功能,提高临床疗效.
Abstract
AIM To investigate the clinical effects of Tongfu Xingshen Decoction combined with abdominal acupuncture plus warm acupuncture and moxibustion on elderly patients with post-stroke cognitive impairment.METHODS Ninety-eight patients were randomly assigned into control group (49 cases) for 1-month intervention of both abdominal acupuncture and warm acupuncture and moxibustion,and observation group (49 cases) for 1-month intervention of Tongfu Xingshen Decoction,abdominal acupuncture and warm acupuncture and moxibustion.The changes in clinical effects,MoCA score,NIHSS score,SDSVD score,ADL score,neurotransmitters (DA,5-HT,NE),hemorheological indices (high shear viscosity,low shear viscosity,plasma viscosity,hematocrit),hemodynamic indices (average blood flow velocity,average blood flow volume,characteristic impedance,dynamic impedance),cell apoptosis indices (Bcl-2,Bax,Caspase3).RESULTS The observation group demonstrated higher total effective rate than the control group (P<0.05).After the treatment,the two groups displayed increased MoCA score,ADL score,neurotransmitters,average blood flow velocity,average blood flow volume,Bcl-2 (P<0.05),and decreased NIHSS score,SDSVD score,hemorheological indices,characteristic impedance,dynamic impedance,Bax,Caspase3 (P<0.05),especially for the observation group (P<0.05).CONCLUSION For the elderly patients with post-stroke cognitive impairment,Tongfu Xingshen Decoction combined with abdominal acupuncture plus warm acupuncture and moxibustion can improve cognitive functions and enhance clinical efficacy.
维普
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