Chemical constituents from Zanthoxylum avicennae and their antibacterial activities
AIM To study the chemical consitituents from Zanthoxylum avicennae (Lam.) DC.and their antibacterial activities.METHODS The 95％ ethanol extract from Z.avicennae was isolated and purified by silica gel,Sephadex LH-20,ODS,TLC and semi-preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.Microdilution broth method was employed to the antibacterial activities of the compounds on methicillin-resistant Staphylococcus aureus (MRSA).RESULTS Fifteen compounds were isolated and identified as friedelin (1),linoleic glyceride (2),b-friedoolean-5-ene-3-β-ol (3),(±)-balanophonin (4),(10E,12Z)-9-hydroxy-10,12-octadecadienoic acid ethyl ester (5),(9Z,12Z,14E)-16-hydroxy-9,12,14-octadecatrienoic acid ethyl ester (6),(S)-24-ergost-4-en-3-one (7),24-propylcholesterol (8),avicennol ethyl ether (9),hydroxytyrosol (10),6,7-dimethylcoumarin (11),(R)-(-)-mellein methyl ether (12),(-)-columbianetin (13),avicennol methyl ether (14),(Z)-avicennone (15).The MIC values of compounds 3,5,9,14-15 were 250μg/mL,the MIC values of compounds 1-2,4,6-8 were 125 μg/mL,and the MIC value of compound 13 was 31.25 μg/mL.CONCLUSION Compounds 1-6 are isolated from genus Zanthoxylum for the first time.Compounds 7-13 are isolated from this plant for the first time.In addition,the carbon spectrum data of compounds 9and 14 are reported for the first time.Compounds 1-9 and 13-15 have antibacterial activities,and compound 13 has strong antibacterial activity.
Zanthoxylum avicennae (Lam.) DC.chemical constituentsisolation and identificationantibacterial activities
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