Chemical constituents from the leaves of Ziziphus jujuba var.spinosa and their anti-inflammatory activities
AIM To study the chemical constituents from the leaves of Ziziphus jujuba Mill.var.spinosa (Bunge) Hu ex H.F.Chou and their in vitro anti-inflammatory activities.METHODS The 70％ ethanol extract from the leaves of Z.jujuba var.spinosa was isolated and purified by various modern chromatographic methods,then the structures of obtained compounds were identified by physicochemical properties and spectral data.Their in vitro anti-inflammatory activities were evaluated by RAW264.7 model.RESULTS Fourteen compounds were isolated and identified as ampelopsisionoside (1),(3S,6S)-cis-linalool-3,7-oxide-β-D-glucopyranoside (2),alangionoside L (3),2-{(2S,5R)-5-[(1E)-4-hydroxy-4-methylhexa-1,5-dien-1-yl]-5-methyltetra-hydrofuran-2-yl} propan-2-yl β-D-glucopyranoside (4),(-)-nectandrin B-β-D-glucopyranoside (5),nikoenoside (6),kiwiionoside (7),dendranthemoside A (8),tormentic acid (9),2α,3β,19α-trihydroxy-urs-12-en-28 oic acid (10),2α-hydroxybetulinic acid (11),2α-hydroxylursolic acid (12),ceanothanolic acid (13),and maslinic acid (14).Compounds 10,11,13 and 14 could inhibit the production of NO in RAW264.7 cells.CONCLUSION Compounds 1,2,4 are first isolated from Rhamnaceae family,and 3,5,6,8 are first isolated from this plant.Compounds 10,11,13 and 14 have significant anti-inflammatory activities.
Ziziphus jujuba Mill.var.spinosa (Bunge) Hu ex H.F.Chouleavessesquiterpenestriterpenoidsisolation and identificationanti-inflammatory activities
万方数据
维普
