摘要
目的 研究白鲜皮化学成分.方法 白鲜皮70％乙醇提取物采用HP-20大孔树脂、硅胶、MCI、ODS及制备HPLC进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构.结果 从中分离得到33个化合物,分别鉴定为芦丁(1)、芹菜素(2)、儿茶素(3)、橙皮素(4)、leonuriside A(5)、草夹竹桃苷(6)、2-methoxy-4-acetylphenol-O-α-rhamnopyranosyl-(1"-6')-β-glucopyranoside(7)、香草酸(8)、没食子酸(9)、4-羟基苯甲酸(10)、苯甲酸(11)、involcranoside B(12)、苄基 β-D吡喃葡萄糖苷(13)、bphenylethyl-rutinoside(14)、1-溴萘(15)、升麻素(16)、9(S),12(S),13(S)-trihydroxyoctadeca-10(E),15(Z)-dienoic acid(17)、methyl-9,12,13-trihydroxyoctadeca-10,15-dienoate(18)、7,8-dihydroxy-9,12(Z,Z)-octadecadienoic acid(19)、斑鸠菊酸(20)、9,10(erythro)-dihydroxy-11E-octadecadienoic acid methyl ester(21)、(7Z,9E,13Z)-11-hydroxyhexadeca-7,9,13-trienoic acid(22)、(7Z,10Z,14E,16Z,19Z)-13-hydroxydocosa-7,10,14,16,19-pentaenoic acid(23)、(9E)-8,11,12-trihydroxyoctadecenoic acid methyl ester(24)、n-hexanol-O-rutinoside(25)、己基 β-槐苷(26)、3-pentyl 6'-(3-hydroxy-3-methylglutaryl)-β-D-glucopyranoside(27)、3-methylbut-3-enyl-6-O-β-D-glucopyranosyl-β-D-glucopyranoside(28)、3-methyl-but-2-en-1-yl β-D-glucopyranoside(29)、3-methylbutan-1-ol-β-D-glucopyranoside(30)、孕烯醇酮(31)、2-butoxytetrahydrofuran(32)、psydrin(33).结论 化合物 2～4、8～13、15～16、25～28、32～33 为首次从芸香科分离得到.
Abstract
AIM To study the chemical constituents from Dictamni Cortex.METHODS The 70％ethanol extract from Dictamni Cortex was isolated and purified by HP-20 macroporous resin,silica gel,MCI,ODS and preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Thirty-three compounds were isolated and identified as rutin(1),apigenin(2),catechin(3),hesperetin(4),leonuriside A(5),androsin(6),2-methoxy-4-acetylphenol-O-α-rhamnopyranosyl-(1"-6')-β-glucopyranoside(7),vanillic acid(8),gallic acid(9),4-hydroxybenzoic acid(10),benzoic acid(11),involcranoside B(12),benzyl β-D-glucopyranoside(13),bphenylethyl-rutinoside(14),1-bromonaphthalene(15),cimifugin(16),9(S),12(S),13(S)-trihydroxyoctadeca-10(E),15(Z)-dienoic acid(17),methyl-9,12,13-trihydroxyoctadeca-10,15-dienoate(18),7,8-dihydroxy-9,12(Z,Z)-octadecadienoic acid(19),vernolic acid(20),9,10(erythro)-dihydroxy-11 E-octadecadienoic acid methyl ester(21),(7Z,9E,13Z)-11-hydroxyhexadeca-7,9,13-trienoic acid(22),(7Z,10Z,14E,16Z,19Z)-13-hydroxydocosa-7,10,14,16,19-pentaenoic acid(23),(9E)-8,11,12-trihydroxyoctadecenoic acid methyl ester(24),n-hexanol-O-rutinoside(25),hexyl β-sophoroside(26),3-pentyl 6'-(3-hydroxy-3-methylglutaryl)-β-D-glucopyranoside(27),3-methylbut-3-enyl-6-O-β-D-glucopyranosyl-β-D-glucopyranoside(28),3-methyl-but-2-en-1-yl β-D-glucopyranoside(29),3-methylbutan-1-ol-β-D-glucopyranoside(30),pregnenolone(31),2-butoxytetrahydrofuran(32),psydrin(33).CONCLUSION Compounds 2-4,8-13,15-16,25-28 and 32-33 are isolated from Rutaceae family for the first time.
维普
万方数据