Residue analysis and dietary risk assessment of dinotefuran and its metabolites in Lycium barbarum L.
UPLC-MS/MS was applied to detect the residues of dinotefuran and its metabolites.Four field trials were designed to analyze the degradation dynamics and final residues of pesticides in Lycium barbarum L.,and estimate the dietary intake risk.This study aims to establish an analytical method for simultaneous determination of dinotefuran and its metabolites in Lycium barbarum L.,analyze its residues in Lycium barbarum L.,and assess the dietary intake risk.The results showed that,the correlation coefficients of the standard curves of dinotefuran and its metabolites were all greater than 0.999,the average recovery rate was 78.6％～96.4％,the RSD was 0.41％～8.30％,and the LOQ was 0.02 mg/kg.The results of storage stability test showed that during the test period of 11 months under the condition of lower than-18 ℃,dinotefuran and its metabolites were relatively stable in the fresh and dried fruits of Lycium barbarum L..The results of digestion dynamic test showed that the metabolites DN and UF of dinotefuran were not detected in the fresh fruit of Lycium barbarum L.in Ningxia and Qinghai,and the half-life of dinotefuran in the fresh fruit of Lycium barbarum L.in Ningxia and Qinghai were 2.9 days and 3.7 days,respectively.The final residue test results showed that the safe interval was 7 days,and the residue of dinotefuran and its metabolites in fresh fruits of Lycium barbarum L.from Ningxia,Qinghai,Hebei and Xinjiang was 0～0.52 mg/kg,and the residue of dinotefuran and its metabolites in dried fruits of Lycium barbarum L.from four places was 0～2.00 mg/kg.The results of dietary risk assessment showed that the dietary intake risk of dinotefuran was 19.3％.This method is simple,efficient,accurate,and practical.Dinotefuran and its metabolites have a long stable storage period in Lycium barbarum L..There will be no risk of dietary intake if used correctly according to the recommended dosage.
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NSTL
万方数据
