Pear ring rot is a fungal disease,which is one of the most serious diseases on pear trees in China.It has a very serious impact on the yield and quality of pear fruit every year,and has hindered the development of fruit industry.Breeding resistant varieties is the most fundamental and effective measure to control the disease.With the development of molecular biology,many scholars have studied the resistance mechanism of pear ring rot disease.It is generally believed that most of the resistance genes of pear and apple are related to the metabolic pathway of salicylic acid.In this paper,based on the literature in recent years,the etiology,pathogenic mechanism and resistance mechanism,resistance evaluation of different germplasm resources,genetic rule of resistance and prevention methods of pear ring rot disease were reviewed,focusing on the molecular mechanism of resistance against pear ring rot disease,and the localization and mining of resistance genes.In order to provide a more scientific basis for breeding for resistance,mapping and mining of resistance-related genes,development of resistance-related molecular markers and comprehensive prevention and control of pear ring rot disease.