Effect of Porcine Reproductive and Respiratory Syndrome on Immunity of Inactivated Seneca virus A Vaccine
In order to explore the effect of Porcine reproductive and respiratory syndrome(PRRS)on the immune effect of inactivated Senecavirus A(SVA)vaccine,the same batch and dose of inactivated SV A vaccine were immunized respectively in PRRS positive pigs and PRRS negative pigs in this experiment.Serum neutralizing antibody titers were detected at 7,14,21 and 28 days after the first immunization,and the challenge protection test was performed on all pigs at 28 days after immunization.The results showed that the titers of all serum neutralizing antibodies of the pigs with PRRS were less than 1:4,while the titers of serum neutralizing antibodies of PRRS negative pigs rose to a high level after the enhanced immunization.The results of challenge protection were positively correlated with the titer of neutralizing antibody.The inactivated SVA vaccine provided 0/5 protection for the PRRSV positive group and 5/5 protection for the PRRS negative group.This study shows that PRRS can reduce the immune effect of inactivated SVA vaccine,which provides a reference for the development of SVA vaccine and PRRS vaccine and the prevention and control of swine diseases.
Senecavirus APorcine reproductive and respiratory syndromeimmunityneutralizing antibody
万方数据
维普
