mRNA vaccine technology is characterized by short development cycles,excellent safety,and strong production technology universality.However,due to the special process of mRNA vaccines,the traditional design concepts of biopharmaceutical production facilities cannot fully meet the requirements for their preparation.The scientific and rational design of production facilities is the main condition to the quality and yield of vaccines.Therefore,how to design the production plant that meets the both process requirements and GMP has become an urgent problem for us to explore.Given the differences in energy structure,environmental protection requirements and design concepts among different countries,based on the scale-up mRNA vaccine production facilities in Europe and the United States and the design of human mRNA vaccine workshops,we proposed the production facilities,process key points and design scheme that comply with the GMP regulations for veterinary drugs in China.This is done in hopes of providing a reference for the domestic industrialization of animal mRNA vaccines plant.
维普
万方数据