A Comprehensive Overview of Approved Animal Brucellosis Live Attenuated Vaccines in China and Novel Vaccine Research Direction
Brucellosis,a severe zoonotic infectious diseases affecting humans and animals in China,poses a significant public health security challenge globally.The incidence of brucellosis in human is closely associated with animal cases.Therefore,implementing effective control measures against brucellosis in livestock is vital for disease management in China.Vaccination has proven to be an effective intervention strategy.So far,China has approved seven brucellosis vaccines:S2 strain,M5/M5-90 strain,M5-90Δ26 strain,Rev.1 strain,A19 strain,A19ΔVirB12 strain and BA0711 strain.This article offers a comprehensive overview of the vaccines,including their background,usage,immunization conditions,vaccine genomes,and protective efficacy.Moreover,this study delves into the potential advancements in the development of novel vaccines that are safe,efficient,capable of differential diagnosis,and non-infectious to individuals.By thoroughly examining the strengths and weaknesses of current vaccines,the research aims to offer valuable insights for the successful implementation of vaccination programs and provide a foundation for future vaccine innovation.
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