Tracking Analysis on the Distribution of Minimal Inhibitory Concentrations of Enterococcus from Pigs and Chickens in Zhejiang Province under Small Sample Quantity
To track and analysis the trends of antibiotic resistance to the restricted and discontinued antibacterial of Enterococcus from pig and chicken in Zhejiang Province,the micro broth dilution method was used to continuously monitor the antibiotic resistance of Enterococcus from 40 pig and chicken farms in Zhejiang Province from 2019 to 2023.Under small sample size conditions,based on the MIC distribution curve,MIC50,and resistance coefficient method,the trend of minimum inhibitory concentration(MIC)of these Enterococcus against seven discontinued and restricted antibiotics,including guitarimycin,xanthomycin,enramycin,nasilide,virginiamycin,bacitracin,and ofloxacin,was evaluated.The results showed that the tolerance level of Enterococcus to bacteriocins from chicken and pig sources showed a significant downward trend;The tolerance levels to guitarimycin,xanthomycin,and enramycin showed an overall downward trend,with guitarimycin and xanthomycin showing an initial increase followed by a decrease,while enramycin showed an initial decrease followed by an increase;The strain is relatively sensitive to both naseptide and virginiamycin,but there is a slight increase in strains with low concentration MIC values;There are species differences in the tolerance to ofloxacin,and chicken derived Enterococcus is relatively sensitive,with a further downward trend in tolerance levels.Pig derived Enterococcus has a relatively high tolerance level to ofloxacin,and the number of medium concentration MIC value bacterial strains has significantly increased in 2022.
small sample quantitytracking analysisEnterococcusantibacterialMICdistribution
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NSTL
万方数据
