The trial was designed to evaluate the efficacy of carprofen injection combined with telamycin injection in the treatment of bovine respiratory disease(BRD)and to determine the appropriate dose to administer.Six-four cattle with BRD,randomly divided into 2 groups,groups A and B,with 32 cows each,among them,group A was administered subcutaneously telamycin injection(recommended dose 2.5 mg/kg·bw)and carprofen injection(phase II confirmed dose 1.4 mg/kg·bw),group B was administered subcutaneously telamycin injection(recommended dose 2.5 mg/kg·bw).All drugs were given only once in all test cattle.The clinical symptoms of each group were recorded during the trial and scored it;the adjuvant treatment efficacy of carprofen injection on bovine respiratory diseases was evaluated by the detection of inflammatory factors,pathogenic bacteria and specific pathogen antigens/antibodies in each test cattle.The results showed that carprofen injection combined with thalamycin injection to treat BRD could eliminate the inflammatory response from pathogen infection in cattle in a shorter time than thalamycin injection alone;Using thalamycin injection alone or in combination with carprofen injection for BRD,the serum PCT concentration in sick cattle decreased significantly(P<0.05),but the decrease in the two drugs was more significant(P<0.05).The results showed that carprofen injection is clinically recommended in combination with telamycin injection,one dose,1.4 mg/kg·bw,which can effectively assist in the treatment of bovine respiratory diseases.
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