卡洛芬注射液辅助治疗牛细菌性呼吸疾病的疗效研究
Study on the Adjuvant Treatment of Bovine Respiratory Diseases by Carprofen Injection
刘静 1王玉欣 1宋婷婷 1耿智霞 1贾兴 1郭李珉 1刘欣 1魏占勇 1曹兴元2
作者信息
- 1. 河北远征药业有限公司,石家庄 050041;河北省兽药技术创新中心,石家庄 050041
- 2. 中国农业大学,北京 100083
- 折叠
摘要
为评价卡洛芬注射液与泰拉霉素注射液联用治疗牛呼吸道疾病(bovine respiratory disease,BRD)的效果,并确定合理的给药剂量,试验选择 64 头患呼吸道疾病的牛,随机分为A、B两组,每组32 头,其中A组皮下注射给予泰拉霉素注射液(推荐剂量2.5 mg/kg·bw),同时肌内注射给予卡洛芬注射液(II期临床试验确认剂量1.4 mg/kg·bw);B组只皮下注射给予泰拉霉素注射液(推荐剂量2.5 mg/kg·bw).所有试验牛各种药均只给予1 次.试验期间观察记录各组牛的临床症状,并对其进行评分;通过对各试验牛的炎症因子、致病菌、特定病原抗原/抗体的检测,评价卡洛芬注射液对牛呼吸道疾病的辅助治疗效果.试验结果显示,相比于单独使用泰拉霉素注射液,卡洛芬注射液与泰拉霉素注射液联用治疗BRD可以在更短时间内消除牛体内病原菌感染带来的炎症反应;泰拉霉素注射液单独使用或与卡洛芬注射液联用治疗BRD,给药3d病牛的血清PCT浓度均明显下降(P<0.05),但两药联用的下降速度更加显著(P<0.05).结果表明,临床上推荐卡洛芬注射液与泰拉霉素注射液联用,皮下注射,一次量为 1.4 mg/kg·bw,可有效辅助治疗牛呼吸道疾病.
Abstract
The trial was designed to evaluate the efficacy of carprofen injection combined with telamycin injection in the treatment of bovine respiratory disease(BRD)and to determine the appropriate dose to administer.Six-four cattle with BRD,randomly divided into 2 groups,groups A and B,with 32 cows each,among them,group A was administered subcutaneously telamycin injection(recommended dose 2.5 mg/kg·bw)and carprofen injection(phase II confirmed dose 1.4 mg/kg·bw),group B was administered subcutaneously telamycin injection(recommended dose 2.5 mg/kg·bw).All drugs were given only once in all test cattle.The clinical symptoms of each group were recorded during the trial and scored it;the adjuvant treatment efficacy of carprofen injection on bovine respiratory diseases was evaluated by the detection of inflammatory factors,pathogenic bacteria and specific pathogen antigens/antibodies in each test cattle.The results showed that carprofen injection combined with thalamycin injection to treat BRD could eliminate the inflammatory response from pathogen infection in cattle in a shorter time than thalamycin injection alone;Using thalamycin injection alone or in combination with carprofen injection for BRD,the serum PCT concentration in sick cattle decreased significantly(P<0.05),but the decrease in the two drugs was more significant(P<0.05).The results showed that carprofen injection is clinically recommended in combination with telamycin injection,one dose,1.4 mg/kg·bw,which can effectively assist in the treatment of bovine respiratory diseases.
关键词
卡洛芬/牛呼吸道疾病/临床疗效Key words
carprofen/dairy cow/bovine respiratory disease/clinical efficacy引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据