Preparation and Quality Study of Altrenogest Tablets
The preparation and quality of altrenogest tablets were studied.Taking the disintegration time and dissolution degree of the drug as the main indexes,the orthogonal design method was used to optimize the prescription,and an altrenogest tablet with delayed disintegration time was prepared to meet the wet feeding needs of different pig farms and environments.The appearance characteristics,hardness,weight difference,fragility,disintegration time,dissolution and content determination of altrenogest tablets were investigated,and the dissolution method of altrenogest tablets was studied.The results showed that the results of appearance traits,hardness,weight differences,fragility,disintegration time,dissolution and content determination of altrenogest tablets met the requirements,and the content was determined to be90.0%～105.0%of the labeled amount.The results of disintegration time and dissolution showed that the disintegration of altrenogest tablets was completed 7～15 minutes after contact with water,and the dissolution was greater than 90%.The disintegration time of the altrenogest tablets obtained in the study was extended by 5～10 minutes,and the dissolution and content reached the standards.Therefore,it was determined that the prescription process of the developed altrenogest tablets was feasible,the quality was controllable,and it met the proposed quality standards.
altrenogest tabletstime limit for disintegrationdissolutionquality study
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