Advances in Research on Proteins and Molecular Mechanisms of the Entry of African Swine Fever Virus
African swine fever virus(ASFV)is the causative agent of African swine fever,which can cause an acute and hemorrhagic disease affecting domestic pigs and wild boars.There is currently no effective vaccine or antiviral drug.ASFV is an enveloped virus,and its envelope protein may be involved in virus invasion and cell tropism.The process of virus entry into cells is the initial step of infecting cell through binding of specific molecules on the cell surface to viral proteins and adsorbing on the host cell surface,so viral proteins or host factors that target ASFV entry may be effective in inhibiting ASFV replication.In this review we summarized the current process in molecular mechanism of ASFV entry into cells,in order to explore the perspective of ASFV membrane protein and its function,which may be important for the development of therapeutic drugs and vaccines.
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