Study on Microbiological Potency Measurement of Neomycin in Compound Nystatin Ointment
In order to improve the accuracy and reliability of the microbiological assay for neomycin in compound nystatin ointment,it was refined and improved.Through the preparation of test strains,the range of antibiotic concentration and the preparation of double discs,the detection indexes of the microbial detection method for neomycin in compound nystatin ointment were clarified,and the obtained method was verified.The results showed that the microbial detection method of neomycin in compound nystatin ointment had a good linear relationship in the range of 4.58～21.84 U/mL,and had the high accuracy,medium and low concentrations was between 97.07%～102.63%.The repeatability and intermediate precision of the method were good(RSD was 1.5%and 1.4%,respectively),and the tolerance and stability of the method were better.Therefore,this method can be used as a routine quality control method for compound nystatin ointment.
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