Research on Process of the Role of African Swine Fever Virus on Host Autophagy
Autophagy is a very conservative lysosomal degradation process of proteins and organelles in eukaryotic cells.The main mechanism of autophagy is to degrade proteins to provide energy to maintain the energy conservation of the organism during starvation,to remove damaged and senescent organelles and misfolded proteins,and to phagocytose pathogens invading the organism.It plays an important role in maintaining cellular homeostasis and host metabolism.African swine fever is an acute,highly lethal disease,and there is no effective commercialized vaccine or drug available for the control of African swine fever.It has been found that some genes of African swine fever inhibit the occurrence of autophagy and thus suppress the innate immune response.Strains missing these genes are not only less virulent,but also promote autophagy to cause a strong immune response when infecting the host.Therefore,studying the mechanism of African swine fever virus and autophagy plays an important role in the development of African swine fever virus vaccines.This review provides an overview of cellular autophagy and the effects of some African swine fever virus genes on autophagy,with the aim of providing theoretical support for the study of the mechanism of the role of autophagy in African swine fever and the development of an African swine fever vaccine.
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