Optimization of One-step Granulating Process of Shuangge Zhixie Granules by Orthogonal Experiment
In order to optimize the one-step granulation process of Shuangge Zhixie granules and provide a theoretical basis for the production process of Shuangge Zhixie granules.This study utilized the ratio of qualified granules and angle of repose as evaluation indexes,designed L9(34)orthogonal experiment with four factors of relative density of liquids,inlet-air temperature,infusion frequency,and spray pressure of the extract are considered factors as evaluation indexes,with three parallel validation tests being conducted.The results showed that the optimum granulating parameters were as follows:the relative density of liquids was 1.20(70 ℃),the inlet-air temperature was 70 ℃,the infusion frequency was 4 Hz,and the spray pressure of the extract was 0.15 MPa.Thus,the optimized one-step granulating process of Shuangge Zhixie granules is stable,reproducible,and applicable for industrial production.
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