Improvement of the Production Process of Tildipirosin
In order to optimize the synthesis process of Tylosin,Tylosin was obtained by amination,nucleophilic substitution,oxidation,and secondary amination.Among them,Dimethyl sulfoxide-pyridine-sulfur tri oxide oxidant was used to oxide the 20 hydroxyl group,which was oxidized to an aldehyde group and capable of adding a piperidine group.Compared with the reported iodine substitution in the literature,this process reduced production costs,reduced the occurrence of side reactions,and improved the yield of tirosin,resulting in a total yield of 43％.This process is simple to prepare and can achieve industrial production.
tildipirosintylosinsynthesisoxide
李有志、魏秀丽、马居良
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Shandong Provincial Key Laboratory of Qμality Safety Monitoring and Risk Assessment for Animal Products,Shandong Center for Qμality Control of Feed and Veterinary Drug,Jinan 250100,China
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