Advances in Infection and Shedding of African Swine Fever Virus
African swine fever is an acute,febrile infectious disease caused by the African swine fever virus,which occurs quickly and has a high mortality rate.Currently,there is no safe,effective commercial vaccine and antiviral drugs,can only cull infected animals.To reduce economic losses,it is necessary to control the epidemic as soon as possible,mastering the transmission route of the infected host,clinical symptoms and detoxification with the virus detoxification pattern can help early detection of the epidemic,ASFV infection route is diverse,mainly including direct contact,indirect contact and through the Ornithodoros and other transmission.ASF manifests itself as acute,subacute and chronic symptoms in the clinic,and different clinical symptoms lead to differences in the time of shedding,virulence duration and viral load.Studying the relationship between the route of virus transmission,clinical signs and virulence of infected strains,and differences in the infectiousness of different hosts can contribute to a comprehensive understanding of ASF and to the prevention and control of ASF.Wild pigs are more susceptible to ASFV infection than domestic pigs.In this paper,the infection routes of ASF,the clinical manifestations of different strains of ASF and the rule of virus-carrying and detoxication are reviewed,which is of great significance to the early diagnosis and monitoring of ASF.
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