Advances in the Research and Application of Monoclonal Antibodies against Classical Swine Fever Virus
Monoclonal antibodies are highly homogeneous antibodies produced by a single B-cell clone against a specific antigenic epitope,and play an important role in differential diagnosis and prevention of epidemics.In 1986,Wensvoort et al.obtained the first monoclonal antibody against CSFV,and since then a number of monoclonal antibodies against CSFV have been prepared both at home and abroad and have been used in immunology research and clinical testing applications.In this paper,the monoclonal antibodies against CSFV E2,Erns and NS3 proteins prepared at home and abroad and their recent progress in the analysis of CSFV antigenicity,antigenic epitope research,and application in the diagnosis and differentiation of swine fever are reviewed,with a view to providing a basis for the research related to swine fever virus.
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