Varroa destructor mite is a kind of parasitic mite,which does great harm to the healthy development of the global beekeeping industry and is the main reason for the decrease of the global bee population.Therefore,the study of tolerance mechanisms and the cultivation of anti-mite bee species are very urgent,in this paper,we reviewed the studies on the mechanism of resistance to the mite from different aspects,such as the harm of the mite,the behavior mechanism and molecular mechanism of bee.