This study aims to systematically explore the various biological activities of bee venom peptides and their potential for clinical applications.As the main component of bee venom,bee venom peptides have garnered significant attention in the biomedical field in recent years due to their extensive pharmacological effects and therapeutic potential.Methods:The study employed a systematic literature review,searching for relevant academic papers,patents,and medical reports from 2004 to the present.Keywords included"bee venom peptides,""antimicrobial,""anti-inflammatory,""anti-tumor,""clinical application,"etc.By screening and analyzing these documents,core data and conclusions related to the biological activities and clinical applications of bee venom peptides were extracted.Results:Bee venom peptides exhibit significant antibacterial and antiviral activities.Multiple studies have confirmed that bee venom peptides can disrupt the cell membranes of bacteria and viruses,inhibiting their growth and replication.Their anti-inflammatory effects are mainly achieved by inhibiting the release of inflammatory factors and reducing oxidative stress responses.Bee venom peptides have shown notable effects in anti-tumor research,capable of inducing apoptosis in tumor cells and significantly inhibiting tumor growth in some animal models.Additionally,bee venom peptides have demonstrated potential in the treatment of diabetes,cardiovascular diseases,and neurodegenerative diseases.In practical applications,bee venom peptides have already been incorporated into various products,such as antimicrobial sprays and anti-inflammatory ointments.However,challenges such as toxicity control,stability,and targeted delivery remain in their clinical applications.Conclusion:As a natural product with multiple biological activities,bee venom peptides hold great promise in the field of clinical applications.Their antimicrobial,antiviral,anti-inflammatory,and anti-tumor effects provide a crucial research foundation for new drug development.In summary,bee venom peptides are expected to become an important bioactive substance for the future treatment of various diseases.
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