Sacbrood virus(SBV)is the most important pathogen that threatens and causes the decline in the population of the Apis cerana cerana.The immune system is the unique way to fight against the infection of pathogens,and the effective immune response is critical to eliminating the pathogens.Therefore,the immune response to virus or its antigens is important to prevention and treatment of CSBV.Here,we briefly review the studies of immune response to CSBV or its antigens and treatment based on the immune response through artificial stimulation.Finally,we hope this review can provide comprehensive consideration for the immune response and immune response-based control measures.