摘要
TCN1编码的蛋白是血清维生素B12（钴胺素）转运过程中重要的结合蛋白，可通过调控血清钴胺素浓度进而影响DNA合成，导致相关疾病的发生。近年来生物信息学分析和相关研究表明，TCN1在肿瘤组织中发挥着癌基因的作用。TCN1通过调控癌转录失调通路、NF-κB通路、TNF信号通路以及影响整合素β4（ITGB4）、丙酮酸脱氢酶复合物（PDHA1）、琥珀酸脱氢酶（SDH）和细胞色素c氧化酶等物质的活性，参与消化道肿瘤细胞的增殖、侵袭和免疫浸润等一系列生物学行为。因此，了解TCN1基因在消化道肿瘤中的作用机制对临床制定肿瘤的诊断和治疗策略具有重要意义。
Abstract
The protein encoded by TCN1 is an important binding protein in the transport of serum vitamin B12, the expression levels of which affect DNA synthesis through the regulation of plasma vitamin B12 levels and thus contribute to the development of related diseases. Recent studies and bioinformatics analysis have shown that TCN1 plays an oncogene role in tumor tissues. TCN1 is involved in the adhesion, migration, proliferation, invasion and other biological behaviors of digestive tract tumor cells by regulating cancer transcriptional dysregulation pathway, NF-κB pathway, TNF signaling pathway, MAPK pathway, and affecting the activities of integrin β4 (ITGB4), pyruvate dehydrogenase complex (PDHA1), succinate dehydrogenase (SDH) and cytochrome c oxidase. Therefore, understanding the mechanism of TCN1 genes in gastrointestinal tumors is important for clinical diagnosis and therapeutic strategy.
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