摘要
胆管癌发病隐匿且恶性程度较高，通常在发现时已达疾病晚期，已丧失根治性手术切除机会。对于晚期胆管癌的姑息性治疗，传统手段常包括胆道支架置入、射频消融术、放化疗等，但胆管癌对放化疗并不敏感。近年来，光动力疗法（PDT）成为了晚期胆管癌患者的另一项选择，作为一种创伤小、不良反应少的治疗方式，逐步应用于晚期胆管癌的姑息性治疗且已取得良好的疗效，引起了学术界的广泛关注。本文从PDT的原理、在胆管癌中的应用及优缺点等方面进行综述。
Abstract
Changiocarcinoma, insidious and highly malignant, is usually at the advanced stage when it is found out, and patients have lost the chance of radical surgical resection. For the palliative treatment of advanced cholangiocarcinoma, traditional methods include biliary stent placement, radiofrequency ablation, chemoradiotherapy and so on, but cholangiocarcinoma is not sensitive to chemoradiotherapy. In recent years, photodynamic therapy (PDT) has become another option for patients with advanced cholangiocarcinoma due to less trauma and adverse effects. It has been gradually applied to the palliative treatment of advanced cholangiocarcinoma and has achieved good results, thus attracts wide attention in the academic community. This paper summarizes the principles, advantages and disadvantages of the application of PDT for changiocarcinoma.
基金项目
省部共建中亚高发病成因与防治国家重点实验室开放课题(SKL-HIDCA-2020-BC)
省部共建中亚高发病成因与防治国家重点实验室开放课题(SKL-HIDCA-2021-12)
新疆维吾尔自治区高校科研计划项目(XJEDU2021I016)
万方数据