基于类器官模型探索肠道与肠道菌群间相互关系的研究进展
Research progress on the relationship between intestinal tract and gut microbiota based on organoid model
王浩元 1王舒 2王娟 2杨建军2
作者信息
- 1. 710021 西安医学院;710032 西安,消化系肿瘤整合防治全国重点实验室
- 2. 710032 西安,消化系肿瘤整合防治全国重点实验室;710032 西安,空军军医大学第一附属医院消化外科
- 折叠
摘要
肠道菌群在人类健康和疾病中的重要性和多样化作用日益得到认识.从宏基因组微生物组测序研究以及从鼠-人种间差异推断因果关系的困难,促进了人类肠道-微生物相互作用的复杂体外模型的发展.本文主要回顾微生物与肠道和结肠上皮共培养的最新进展,并将快速发展的类器官模型与传统标准模型进行比较,描述肠道微生物和上皮细胞相互作用的具体个体过程如何在体外重现,同时讨论肠道类器官与微生物共培养模型的优势及其临床应用前景,探索个体化治疗的新方向.
Abstract
The importance and diversification of gut microbiota in human health and disease are increasingly recognized.The difficulties in inferring causal relationships from metagenomic microbiome sequencing studies and differences between mouse and human species have promoted the development of complex in vitro models of human gut microbiome interactions.This article will review the latest progress in co-culture of microorganisms with intestinal and colonic epithelium,and compare the rapidly developing organoid model with other standard model,describe how the specific individual process of microbial epithelial interaction can be reproduced in vitro and discuss the advantages of co-cultivation models of human gut microbiota and organoid model in clinical application prospects,so as to explore the new direction of individualized treatment.
关键词
类器官/胃肠道微生物组/共同培养技术/个体化治疗Key words
Organoids/Gastrointestinal microbiome/Coculture techniques/Personalized treatment引用本文复制引用
基金项目
陕西省重点产业创新链(群)社会发展领域重点研发计划(2022ZDLSF03-04)
空军军医大学临床研究项目(2022LC2212)
出版年
2024
NETL
NSTL
万方数据