Phosphoenolpyruvate carboxykinase-1 ( PCK1 ) is one of the key enzymes in the gluconeogenesis pathway in vivo. In recent years,studies have confirmed that PCK1 plays a key regulatory role in the occurrence and development of various tumors such as gastrointestinal tumors,renal clear cell carcinoma,breast cancer,and melanoma. Based on the overview of PCK1,this article focuses on the unique role of PCK1 in tumor differential expression,signal transduction,physiological processes,and regulation of tumor drug sensitivity,aiming to provide new ideas for clinical development of anticancer drugs.
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