首页|Recommendations for the diagnosis and treatment of paroxysmal kinesigenic dyskinesia:an expert consensus in China

Recommendations for the diagnosis and treatment of paroxysmal kinesigenic dyskinesia:an expert consensus in China

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Paroxysmal dyskinesias are a group of neurological diseases characterized by intermittent episodes of involuntary movements with different causes.Paroxysmal kinesigenic dyskinesia (PKD) is the most common type of paroxysmal dyskinesia and can be divided into primary and secondary types based on the etiology.Clinically,PKD is characterized by recurrent and transient attacks of involuntary movements precipitated by a sudden voluntary action.The major cause of primary PKD is genetic abnormalities,and the inheritance pattern of PKD is mainly autosomal-dominant with incomplete penetrance.The proline-rich transmembrane protein 2 (PRRT2) was the first identified causative gene of PKD,accounting for the majority of PKD cases worldwide.An increasing number of studies has revealed the clinical and genetic characteristics,as well as the underlying mechanisms of PKD.By seeking the views of domestic experts,we propose an expert consensus regarding the diagnosis and treatment of PKD to help establish standardized clinical evaluation and therapies for PKD.In this consensus,we review the clinical manifestations,etiology,clinical diagnostic criteria and therapeutic recommendations for PKD,and results of genetic analyses in PKD patients performed in domestic hospitals.

Paroxysmal kinesigenic dyskinesiaDiagnosis and treatmentExpert consensusChina

Li Cao、Xiaojun Huang、Ning Wang、Zhiying Wu、Cheng Zhang、Weihong Gu、Shuyan Cong、Jianhua Ma、Ling Wei、Yanchun Deng、Qi Fang、Qi Niu、Jin Wang、Zhaoxia Wang、You Yin、Jinyong Tian、Shufen Tian、Hongyan Bi、Hong Jiang、Xiaorong Liu、Yang Lü、Meizhen Sun、Jianjun WU、Erhe Xu、Tao Chen、Xu Chen、Wei Li、Shujian Li、Qinghua Li、Xiaonan Song、Ying Tang、Ping Yang、Yun Yang、Min Zhang、Xiong Zhang、Yuhu Zhang、Ruxu Zhang、Yi Ouyang、Jintai Yu、Quanzhong Hu、Qing Ke、Yuanrong Yao、Zhe Zhao、Xiuhe Zhao、Guohua Zhao、Furu Liang、Nan Cheng、Jianhong Han、Rong Peng、Shengdi Chen、Beisha Tang

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Department of Neurology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China

Department of Neurology,The Sixth People's Hospital,Shanghai Jiaotong University,Shanghai,China

Department of Neurology and Institute of Neurology,The First Affiliated Hospital,Fujian Medical University

Fujian Key Laboratory of Molecular Neurology,Fujian Medical University,Fuzhou,China

Department of Neurology and Research Center of Neurology,The Second Affiliated Hospital

Key Laboratory of Medical Neurobiology of Zhejiang Province,Zhejiang University School of Medicine,Hangzhou,China

Department of Neurology,The First Affiliated Hospital,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases

National Key Clinical Department and Key Discipline of Neurology,Guangzhou,China

Department of Neurology,China-Japan Friendship Hospital,Movement Disorder and Neurogenetics Research Center,Beijing,China

Department of Neurology,Shengjing Hospital of China Medical University,Shenyang,China

Department of Neurology,The First Affiliated Hospital of Xinjiang Medical University,Urumqi,China

Department of Neurology,The First Affiliated Hospital of Anhui Medical University,Collaborative Innovation Center for Neuropsychiatric Disorders and Mental Health,Anhui Medical University

Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders,Hefei,China

Department of Neurology,Xijing Hospital,Fourth Military Medical University,Xi'an,China

Department of Neurology,The First Affiliated Hospital of Soochow University,Suzhou,China

Department of Neurology,The First Affiliated Hospital of Nanjing Medical University,Nanjing,China

Department of Neurology,The First Affiliated Hospital of Guangxi Medical University,Nanning,China

Department of Neurology,Peking University First Hospital,Beijing,China

Department of Neurology,Changzheng Hospital,the PLA Naval Medical University,Shanghai,China

Department of Neurology and Department of Emergency,Guizhou Provincial People's Hospital,Guiyang,China

Department of Neurology,Affiliated Hospital of Guizhou Medical University,Guiyang,China

Department of Neurology,Beijing Friendship Hospital,Capital Medical University,Beijing,China

Department of Neurology,Xiangya Hospital,Central South University,Changsha,China

National Clinical Research Center for Geriatric Diseases,Central South University

Key Laboratory of Hunan Province in Neurodegenerative Disorders,Central South University

Laboratory of Medical Genetics,Central South University,Changsha,China

Institute of Neuroscience and The Second Affiliated Hospital of Guangzhou Medical University,Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China,Guangzhou,China

Department of Geriatrics,The First Affiliated Hospital of Chongqing Medical University,Chongqing,China

Department of Neurology,the First Hospital of Shanxi Medical University,Taiyuan,China

Department of Neurology,Huashan Hospital,Fudan University,Shanghai,China

National Clinical Research Center for Aging and Medicine,Huashan Hospital,Fudan University,Shanghai,China

Department of Neurology,Xuanwu Hospital,Capital Medical University,National Clinical Research Center for Geriatric Diseases,Beijing,China

Department of Neurology,Hainan General Hospital,Haikou,China

Department of Neurology,Shanghai Eighth People's Hospital Affiliated to Jiang Su University,Shanghai,China

Department of Neurology,Beijing Tiantan Hospital,Capital Medical University

China National Clinical Research Center for Neurological Diseases

Center of Stroke,Beijing Institute for Brain Disorders

Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease,Beijing,China

Department of Neurology,Henan Provincial People's Hospital,Zhengzhou University People's Hospital,Zhengzhou,China

Department of Neurology,Affiliated Hospital of Guilin Medical University,Guilin Medical University

Guangxi Key Laboratory of Brain and Cognitive Neuroscience,Guilin Medical University,Guangxi Clinical Research Center for Neurological Diseases,Affiliated Hospital of Guilin Medical University,Guilin Medical University

Guangxi Key Laboratory of Brain and Cognitive Neuroscience,Guilin Medical University,Guilin,China

Department of Neurology and Neuroscience Center,First Hospital of Jilin University,Changchun,China

Department of Neurology,The First Affiliated Hospital of Harbin Medical University,Harbin,China

Department of Neurology,and Neuroscience Center,General Hospital of Ningxia Medical University,Key Laboratory of Craniocerebral Diseases of Ningxia Hui Autonomous Region,Yinchuan,China

Department of Neurology,Jiangxi Provincial People's Hospital Affiliated with Nanchang University,Nanchang,China

Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China

Department of Geriatrics and Neurology,The Second Affiliated Hospital and Yuying Children's Hospital,Wenzhou Medical University,Wenzhou,China

Department of Neurology,Guangdong Neuroscience Institute,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou,China

Department of Neurology,The Third Xiangya Hospital,Central South University,Changsha,China

Department of Neurology,First Affiliated Hospital,China Medical University,Shenyang,China

Department of Neurology,Qinghai Provincial People's Hospital,Qinghai,China

Department of Neurology,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China

Department of Neurology,Guizhou Provincial People's Hospital,Medical School of Guizhou University,Guiyang,China

Department of Neurology,the Third Hospital of Hebei Medical University,Shijiazhuang,China

Department of Neurology,Qilu Hospital,Shandong University,Jinan,China

Department of Neurology,the Fourth Affiliated Hospital,Zhejiang University School of Medicine,Yiwu,China

Department of Neurology,Baotou Central Hospital,Baotou,China

Institute of Neurology,Hospital Affiliated with Anhui University of TCM,Hefei,China

Department of Neurology,Second Affiliated Hospital of Kunming Medical University,Kunming,China

Department of Neurology,West China Hospital,Sichuan University,Chengdu,China

State Key Laboratory of Medical Genetics,Changsha,China

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2021

转化神经变性病(英文)

转化神经变性病(英文)

ISSN:
年,卷(期):2021.10(1)
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