摘要
目的 探讨Ⅱ型神经纤维瘤病(neurofibromatosis type Ⅱ,NF2)的临床特征及预后危险因素.方法 回顾性分析2009年至2023年首都医科大学附属北京天坛医院神经外科肿瘤病房108例NF2患者的临床资料,探讨影响患者预后的危险因素.结果 单因素分析结果显示,年龄、性别、颅高压症状、肿瘤直径、术后带插管、吸烟史、慢病、对患者预后无显著影响(P>0.05);病程、肿瘤个数、椎管占位、压迫脑干、KPS<70分、低蛋白血症及CES-D≥16分对预后影响显著(P<0.05).多因素回归分析显示KPS<70分、低蛋白血症及CES-D≥16分是影响患者预后的独立风险因素(P<0.05).结论 NF2患者的临床预后不够理想,与KPS<70分、低蛋白血症及CES-D有关.
Abstract
To investigate the clinical characteristics and prognostic risk factors of neurofibromatosis type Ⅱ(NF2).Methods The clinical data of 108 patients with NF2 admitted to the Department of Neurosurgery,Beijing Tiantan Hospital,Capital Medical University from 2009 to 2023 were retrospectively analyzed,and the risk factors affecting patient prognosis were explored.Results Univariate analysis demonstrated that age,gender,cranial hypertension symptoms,tumor diameter,postoperative intubation,smoking history,and chronic disease exerted no significant influence on the prognosis of patients(P>0.05),whereas the prognosis was significantly impacted by the disease course,the number of tumors,spinal canal occupation,brain stem compression,KPS<70 scores,hypoproteinemia,and CES-D≥16 scores(P<0.05).Multivariate regression analysis indicated that KPS<70 score,hypoproteinemia,and CES-D≥16 score were independent risk factors influencing the prognosis of patients(P<0.05).Conclusions The clinical prognosis of NF2 patients is suboptimal,which is associated with KPS<70,hypoproteinemia,and CES-D.
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