Recent advance in role of immune-related genes in Alzheimer's disease
贾丽娜 1朱晓峰 2尹昌浩 2刘凯
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作者信息
1. 牡丹江医学院研究生院，牡丹江 157011
2. 牡丹江医学院附属红旗医院神经内科，黑龙江省缺血性脑卒中防治重点实验室，牡丹江 157011
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摘要
近年来免疫系统被认为与阿尔茨海默病（AD）的发生发展密切相关，全基因组关联研究目前已确定了许多与免疫反应、小胶质细胞相关的AD风险基因。本文现以免疫相关的AD风险基因为对象，围绕其生物学功能及在AD中的可能作用进行综述，以期为AD的早期防治提供新的科学依据。 Immune system is thought to be closely associated with Alzheimer's disease (AD) in recent years. Genome-wide association studies have identified many AD risk genes related to immune response and microglia. This paper mainly reviews immune-related AD risk genes, describing their biological functions and possible roles in AD, in order to provide new scientific basis for early prevention and treatment of AD.
Abstract
Immune system is thought to be closely associated with Alzheimer's disease (AD) in recent years. Genome-wide association studies have identified many AD risk genes related to immune response and microglia. This paper mainly reviews immune-related AD risk genes, describing their biological functions and possible roles in AD, in order to provide new scientific basis for early prevention and treatment of AD.
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