细胞膜修饰纳米粒子（NPs）作为一种新型的治疗脑部恶性肿瘤的手段，近年来受到广泛关注。该方法通过保留源细胞膜的特性，提高了NPs的靶向性、生物相容性和体内循环时间，可确保药物高效作用于颅内病灶。本文围绕近年该领域研究进展，尤其是细胞膜修饰NPs穿透血脑屏障、免疫逃逸、药物输送的优势，以及不同细胞膜修饰NPs的效果进行综述，以期为脑部恶性肿瘤的治疗提供新的视角。 Cell membrane-modified nanoparticles (NPs) have attracted widespread attention as a new approach for malignant brain tumors in recent years. This method can enhance the targeting, biocompatibility, and circulation time of NPs by preserving the characteristics of source cell membrane, thereby ensuring efficient drug delivery to intracranial lesions. This paper focuses on the research progress in this field, especially advantages of NPs penetrating the blood-brain barrier, immune evasion and drug delivery, as well as modified effect of different cell membrane on NPs, in order to provide help for treatment of malignant brain tumors.
Abstract
Cell membrane-modified nanoparticles (NPs) have attracted widespread attention as a new approach for malignant brain tumors in recent years. This method can enhance the targeting, biocompatibility, and circulation time of NPs by preserving the characteristics of source cell membrane, thereby ensuring efficient drug delivery to intracranial lesions. This paper focuses on the research progress in this field, especially advantages of NPs penetrating the blood-brain barrier, immune evasion and drug delivery, as well as modified effect of different cell membrane on NPs, in order to provide help for treatment of malignant brain tumors.
关键词
细胞膜修饰/纳米载药系统/脑部/恶性肿瘤/血脑屏障/靶向治疗
Key words
Cell membrane modification/Nanoparticle drug delivery system/Brain/Malignant brain tumor/Blood-brain barrier/Targeted therapy
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