不宁腿综合征（RLS）是常见的感觉运动障碍性疾病，虽然不会对生命造成威胁，但严重影响患者的生活质量。RLS的发病机制目前尚不明确，其发病与多种风险因素相关，包括遗传因素和非遗传因素。遗传因素涉及骨髓嗜病毒整合位点1（MEIS1）、BTB结构蛋白9（BTBD9）、增殖蛋白激酶5（MAP2K5）、酪氨酸磷酸酶D（PTPRD）等20余种风险基因，非遗传因素包括地域、年龄、性别、肥胖、内科相关疾病、神经精神疾病及药物等。本文围绕RLS发病风险因素及其相关机制的研究进展进行综述，以期为全面了解RLS发病机制、促进其早期预防及有效治疗提供参考。 Restless legs syndrome (RLS) is a common sensorimotor disorder。 Although it does not pose a threat to life， it seriously affects the quality of life of patients。 RLS pathogenesis is still unclear， and its incidence is associated with a variety of risk factors， including genetic factors and non-genetic factors。 Genetic factors involve more than 20 risk genes， such as meis homeobox 1 (MEIS1)， BTB domain containing 9 (BTBD9)， mitogen-activated protein kinase kinase 5 (MAP2K5)， and protein tyrosine phosphatase receptor type Db (PTPRD)。 Non-genetic factors include regional age， gender， obesity， medical related diseases， neuropsychiatric diseases and drugs。 This paper reviews the recent advance in risk factors and related pathogenesis of RLS to provide references for early prevention and treatment of the disease。
Recent advance in risk factors related to restless leg syndrome
Restless legs syndrome (RLS) is a common sensorimotor disorder. Although it does not pose a threat to life, it seriously affects the quality of life of patients. RLS pathogenesis is still unclear, and its incidence is associated with a variety of risk factors, including genetic factors and non-genetic factors. Genetic factors involve more than 20 risk genes, such as meis homeobox 1 (MEIS1), BTB domain containing 9 (BTBD9), mitogen-activated protein kinase kinase 5 (MAP2K5), and protein tyrosine phosphatase receptor type Db (PTPRD). Non-genetic factors include regional age, gender, obesity, medical related diseases, neuropsychiatric diseases and drugs. This paper reviews the recent advance in risk factors and related pathogenesis of RLS to provide references for early prevention and treatment of the disease.
Restless legs syndromeRisk factorGenetic factorNon-genetic factorPathogenesis
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