Research progress of fibroblast reprogramming and wound repair
Skin wound is one of the most common clinical diseases,and the outcome of wound healing includes regenerative repair and fibrosis repair.As the leading form of adult tissue and organ repair,fibrosis repair,also known as scar repair,will not only lead to tissue and organ dysfunction of patients,affect the appearance and physical and mental health,but also increase the medical and economic burden of the country.Therefore,how to inhibit fibrosis repair and promote regenerative repairin wound healing,so as to further maintain the integrity and function of the injured skin has been a major problem of medicine.In recent years,the development of stem cells and reprogramming techniques has brought conceptual innovation to regenerative medicine.And fibroblast reprogramming provides a new technical support for regenerative repair of large area burn and severe trauma.In this paper,the biological characteristics of skin fibroblasts are summarized,and the recent research progress of fibroblast reprogramming in wound repair is reviewed.
万方数据
维普
