Objective To evaluate the causal relationship between inflammatory factors,plasma metabolites and knee osteoarthritis ( KOA) and the mediating effect of plasma metabolites in inflammatory factor-mediated KOA using Mendelian randomization (MR) system. Methods The genome-wide association study ( GWAS) data of 91 inflammatory factors,1400 plasma metabolites and KOA were obtained from the public GWAS database. Two-sample MR analysis was used to evaluate the causal relationship between inflammatory factors,metabolites and KOA and KOA-related inflammatory factors and metabolites,and then the mediating effect of metabolites in inflammatory factor-mediated KOA was estimated. Results 2 inflammatory factors ( CD5,FGF-5) and 65 plasma metabolites were found to have significant causal relationships with KOA. Mediation analysis found that N-acetyl-1-methylhistidine had a 3.7％ mediating effect ratio in the causal relationship between FGF-5 and KOA. Conclusion A variety of inflammatory factors and metabolites have a causal relationship with KOA,and the effect of metabolism on KOA should be paid attention to. The role of T cells in the prevention of KOA is confirmed,and the anti-inflammatory effect of leukocyte-rich platelet-rich plasma is explained from the genetic level. The potential of FGF pathway to prevent KOA isidentified,which provides a reference for future studies of PRP components.
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万方数据