The role of cell-crystal reaction mediated inflammation in the formation of intrarenal calcium oxalate crystals
Calcium oxalate nephrolithiasis is the common disease of urinary surgery,its exact pathogenesis is still unclear.It is believed that the renal inflammatory injury induced by cell-crystal reaction plays an important role in the formation of intrarenal calcium oxalate crystals.Recent studies indicated that inflammation induced by cell-crystal reaction can cause renal cell damage,stimulate intracellular expression of NADPH oxidase,trigger the massive production of reactive oxygen species,activate nuclear factor-κB signaling pathway,release a large number of inflammatory factors,and cause inflammatory cascade effect of the kidney,thus promoting the accumulation,nucleation and growth of calcium salt crystals,eventually leading to the formation of intrarenal crystals and even stones.In this process,the regulatory factors and mechanisms involved include macrophages,NLRP3-high mobility group box-1 protein inflammation network,fetuin A,autophagy activation and other factors.
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