Objective To investigate the effect of laparoscopic splenectomy and azygoportal disconnection(LSD)on liver synthesis and development of liver cirrhosis.Methods This is a prospective case series study.The clinical data of liver cirrhotic patients with portal hypertension who received LSD at the Department of Hepatobiliary Surgery of Northern Jiangsu People's Hospital Affiliated to Yangzhou University from September 2014 to January 2016 were included.This study analyzed the diameter of the portal vein,the velocity of portal blood flow,the routine blood parameters,the liver function,the synthetic proteins of liver(antithrombin Ⅲ(AT-Ⅲ),protein S,protein C),and the serum content of liver fibrotic markers(collagen type Ⅳ,procollagen type Ⅲ,laminin,hyaluronidase).Repeated measures ANOVA was used for comparison between multiple groups,and least significance difference was used for post-hoc multiple comparison.Results A total of 106 patients were included in the study,including 70 males and 36 females,aged(51.8±9.8)years(range:28 to 75 years).Compared with the preoperative results,the diameter of portal vein and the velocity of portal vein decreased after surgery(F=14.03,12.15,respectively,both P＜0.01).Compared with the preoperative results,the total bilirubin,albumin,prothrombin time,international normalized ratio,Child-Pugh score and classification were improved(F=17.96,56.01,66.63,35.83,33.49,and 27.50,respectively,all P＜0.01),and the AT-Ⅲ,protein S,protein C,collagen type Ⅳ,procollagen type Ⅲ,laminin and hyaluronidase levels were also improved(F=47.87,36.26,18.02,22.79,14.58,44.35,and 14.38,respectively,all P＜0.01).Compared with the preoperative period,the diameter of portal vein was reduced from the first week to the 24thh month after surgery(t=5.45 to 9.39,all P＜0.01).Compared with the preoperative period,the velocity of portal vein blood from the first week after surgery to the 24th month after surgery was decreased(t=4.02 to 8.43,all P＜0.01).Compared with the preoperative period,routine blood parameters(white blood count,hemoglobin,platelet count),liver function(total bilirubin,albumin,prothrombin time,international normalized ratio,Child-Pugh score),liver synthetic protein(AT-Ⅲ,protein S,protein C)and liver fibrotic markers(collagen type Ⅳ,procollagen type Ⅲ,laminin,hyaluronidase)were improved to varying degrees at the 24th month after surgery(t=-20.46 to 11.93,all P＜0.01).Conclusion Preliminary findings show that LSD can reduce portal vein pressure,restore blood cell number,and improve liver synthesis function and the degree of liver fibrosis in patients with portal hypertension in liver cirrhosis.
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