Objective To investigate the efficacy of Kirschner wire prying and hollow screw fixation in treating Sanders typeⅢ calcaneal fracture through sinus tarsi approach.Methods 72 patients with Sanders type Ⅲ calcaneal fracture who underwent surgical treatment in Zhongnan Hospital of Wuhan University from March 2021 to December 2022 were selected as the study objects,and were divided into minimally invasive group and traditional group according to different surgical methods.In the minimally invasive group,35 cases were treated by prying out and reducing hollow screws through tarsal sinus incision,and in the traditional group,37 cases were treated by traditional lateral"L"incision approach plate internal fixation.Compare two groups of postoperative the American Orthopedic Foot and Ankle Society(AOFAS)after ankle-foot function score,visual analogue scale method(VAS)score,excellent and good rate of treatment,complications,calcaneal imaging parameters,fracture healing time,and treatment satisfaction.Results At the last follow-up,bone healing was achieved in both groups,and the AOFAS score in the minimally invasive group was higher than that in the traditional group,the difference was statistically significant(P<0.05).There were no statistically significant differences in VAS score,excellent and good rate,Böhler angle,Gissane angle and fracture healing time between the two groups(P>0.05).The total incidence of local incision complications in minimally invasive group was lower than that in traditional group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of traumatic arthritis between the two groups(P>0.05).Treatment satisfaction in minimally invasive group was higher than that in traditional group,and the difference was statistically significant(P<0.05).Conclusion The treatment of Sanders type Ⅲ calcaneal fracture by prying and repositioning hollow screw fixation through the tarsal sinus incision has good fracture restoration and fixation,and the incidence of incision skin infection and necrosis is low,so it is worth to be promoted and applied.