呼吸道合胞病毒(respiratory syncytial virus, RSV)是急性呼吸道感染的主要病原体之一，给全世界造成了巨大的负担。病毒与宿主细胞受体识别和相互作用，是建立感染的关键初始步骤，受体分布影响病毒的细胞嗜性和组织嗜性，影响病毒在宿主体内的复制和增殖。但目前RSV受体尚不明确，这也是阻碍RSV疫苗及治疗性药物研发的原因之一。本文通过对现有的RSV受体进行综述，以期对RSV疫苗及治疗性药物的研发提供思路。 Respiratory syncytial virus (RSV) is one of the major pathogens of acute respiratory infections, becoming a huge global burden. Virus-receptor interactions play a key role in the pathogenesis of RSV infection. The distribution of receptors influences the cellular and the tissue tropism of RSV as well as the viral replication and proliferation in the host. However, the RSV receptors are currently unknown, which is one of the reasons that hinders the development of RSV vaccines and therapeutic drugs. In this study, the existing RSV receptors are reviewed with the hope to provide ideas for the research of RSV vaccines and therapeutic drugs.
Research progess in respiratory syncytial virus receptors
Respiratory syncytial virus (RSV) is one of the major pathogens of acute respiratory infections, becoming a huge global burden. Virus-receptor interactions play a key role in the pathogenesis of RSV infection. The distribution of receptors influences the cellular and the tissue tropism of RSV as well as the viral replication and proliferation in the host. However, the RSV receptors are currently unknown, which is one of the reasons that hinders the development of RSV vaccines and therapeutic drugs. In this study, the existing RSV receptors are reviewed with the hope to provide ideas for the research of RSV vaccines and therapeutic drugs.
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