Islet transplantation is the most effective method to restore endogenous insulin secretion and control blood glucose， but there are still problems such as low survival rate， decline of long-term function and immune rejection of islet grafts. Mesenchymal stem cells （MSCs） have attracted much attention due to their ability to secrete the extracellular matrix （ECM） with a variety of cytokines， or promoting the restoration of cellular injury， angiogenesis and anti-inflammatory effects through direct cell-cell interaction. MSCs for islet transplantation has the advantages of wide source，low immunogenicity， and can effectively solve the problems of low survival rate， poor function and immune response of islet grafts， so they has become a research hotspot in islet transplantation. This paper reviews progress in MSCs in islet transplantation， including the role of MSCs and their secreted cytokines in islet culture in vitro， transplantation research in vivo and clinical application， as well as the problems in the application of MSCs， aiming to further promote the application of MSCs in clinical islet transplantation.
傅红兴、王植楷、谢贵林、蔡娟娟、杨威、严盛
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1.310003 杭州，浙江大学医学院附属第二医院肝胆胰外科
2.310003 杭州，19104-5160 Pennsylvania， School of Arts and Sciences， University of Pennsylvania， Philadelphia， USA
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