Diagnostic values of serum GDF15,sB7-H1 combined with multi-slice spiral CT perfusion imaging technology for lymph node metastasis in gastric cancer patients
Objective Exploring the diagnostic values of serum growth differentiation factor 15(GDF15),soluble B7-H1(sB7-H1)combined with multi-slice spiral CT(MSCT)perfusion imaging for lymph node metastasis in gastric cancer patients.Methods A total of 96 gastric cancer patients admitted to Shandong Provincial Hospital from May 2021 to May 2023 were selected as the study group.Patients in the study group were divided into a metastatic group(41 cases)and a non metastatic group(55 cases)based on the presence or absence of lymph node metastasis.Additionally,96 patients with benign gastric diseases during the same period were selected as the control group.The Spearman method was used to analyze the correlation between the expression levels of serum GDF15,sB7-H1 and MSCT parameters in patients;Logistic regression analysis was used to analyze the related factors affecting lymph node metastasis in gastric cancer patients;The diagnostic values of serum GDF15,sB7-H1 and MSCT parameters in lymph node metastasis of gastric cancer patients were analyzed using receiver operating characteristic(ROC)curve.Results There was a statistically significant difference in MSCT parameters among three groups(P<0.05);The expression levels of serum GDF15 and sB7-H1 in the metastatic group were higher than those in the control group and non metastatic group(P<0.05);The expression levels of serum GDF15 and sB7-H1 were negatively correlated with the blood volume(BV)and bleeding flow(BF)in the lesion area,and positively correlated with the mean transit time(MTT)and surface permeability(PS)of the contrast agent(P<0.05);The proportions of patients with tumors≥2 cm and infiltration depth in the submucosal layer in the metastatic group were significantly higher than those in the non metastatic group(P<0.05);Tumor size,depth of invasion,GDF15 and sB7-H1 were risk factors for lymph node metastasis in gastric cancer patients(P<0.05);The area under the curve(AUC)of serum GDF15,sB7-H1 and MSCT for diagnosing lymph node metastasis in gastric cancer patients were 0.867,0.804,0.740,0.855,0.580 and 0.655,respectively.The AUC of serum GDF15,sB7-H1 combined with MSCT was 0.965,which was superior to the separate detection of serum GDF15,SB7-H1 and MSCT(Zcombined-GDF15=2.788,Zcombined-sB7-H1=3.888,Zcombined-BV=4.837,Zcombined-MTT=3.255,Zcombined-BF=6.281,Zcombined-PS=5.529,all P<0.05).Conclusion The expression levels of serum GDF15 and sB7-H1 are closely related to the occurrence of lymph node metastasis in gastric cancer patients,and the combination of the two and MSCT has high diagnostic value for lymph node metastasis in gastric cancer patients.