首页|慢传输型便秘分子机制研究及临床应用现状

慢传输型便秘分子机制研究及临床应用现状

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慢性便秘是最常见的胃肠道症状之一,而慢传输型便秘是各类型慢性便秘中最难治疗的,慢传输型便秘以结肠传输延迟为特征,无出口梗阻,当药物难以治疗后,则需要结肠切除术或次全切术.慢传输型便秘病因机制复杂,致病机制目前尚未明确,研究主要集中于肠道神经系统的病理改变、胃肠Cajal间质细胞改变、神经递质和胃肠激素的异常、肠内液体吸收等的影响.现在许多新的研究方法蓬勃发展,有希望为慢传输型便秘发病机制的深入研究提供新的思路.
Current status of molecular mechanisms research and clinical applications in slow-transmission constipation
Chronic constipation is one of the most common gastrointestinal symptoms,and slow-transmission constipation(STC)is the most difficult to treat among all types of chronic constipation.STC is characterized by delayed colonic transmission without outlet obstruction and requires colectomy or subtotal resection when medication is difficult to treat.The etiology of STC is complex and the pathogenesis is not yet clear,and research has focused on pathological changes in the enteric nervous system,the gastrointestinal Cajal interstitial cell alterations,abnormalities in neurotransmitters and gastrointestinal hormones,and the effects of intestinal fluid absorption.Nowadays,many new research methods are flourishing,which are promising to provide new ideas for the in-depth study of the pathogenesis of STC.

Slow-transmission constipationMolecular mechanism

黄涔、朱跃坤

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150001 哈尔滨医科大学附属第一医院结直肠外科

慢传输型便秘 分子机制

国家自然科学基金

82272696

2024

中华消化病与影像杂志(电子版)
中华医学会

中华消化病与影像杂志(电子版)

CSTPCD
影响因子:0.641
ISSN:2095-2015
年,卷(期):2024.14(1)
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