Correlation analysis of the influence of Helicobacter pylori infection on nonalcoholic fatty liver disease and coronary atherosclerosis in middle-aged and elderly people
Objective To evaluate the effect of Helicobacter pylori(Hp)infection on nonalcoholic fatty liver disease(NAFLD)and coronary atherosclerosis(CA)in middle-aged and elderly people and analyze the correlation.Methods A total of 234 middle-aged and elderly patients who underwent physical examinations between August 2018 and July 2022 were selected as the research subjects.Based on the presence of Hp infection,the subjects were divided into Hp uninfected group and Hp infected group.The clinical data,fatty liver levels,coronary artery calcification levels,and blood biochemical indicators levels between the two groups were compared.The relationship between NAFLD,CA,and Hp infection through Logistic multiple factor regression analysis was explored.The correlation between NAFLD and CA through Spearman test was explored.Results Body mass index(BMI),age,proportion of hypertension,proportion of diabetes,proportion of hyperlipidemia,blood glucose,alanine aminotransferase(ALT),aspartic transaminase(AST),total bilirubin(TBiL),direct bilirubin(DBiL),total cholesterol(TC),triacylglycerol(TG),low density lipoprotein(LDL),tumor necrosis factor-α(TNF-α),interleukin(IL)-6 and IL-12 in Hp infected group were significantly higher than those in Hp uninfected group,while high-density lipoprotein(HDL)and IL-10 in Hp infected group were significantly lower than those in Hp uninfected group(P<0.05).The incidence rate and severity of NAFLD and CA in Hp infection group were significantly higher than those in Hp uninfected group(P<0.05).Multivariate Logistic regression analysis showed that BMI,ALT,TBiL,TNF-α,IL-10,NAFLD,and CA were independent risk factors affecting Hp infection in subjects.Spearman test showed a positive correlation between NAFLD and CA severity in the Hp infected and non-infected groups.Conclusion There is a strong correlation between Hp infection and NAFLD and CA in the middle-aged and elderly population.The liver and cardiovascular complications of Hp should be given more attention in clinical practice.
Helicobacter pyloriNon alcoholic fatty liver diseaseCoronary atherosclerosisMiddle aged and elderly population
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NSTL
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