Correlation between preoperative plasma fibrinogen,blood lipid level,MMR expression and pathological characteristics and prognosis of colorectal cancer
Objective To analyze the correlation between preoperative plasma fibrinogen(FIB),blood lipid level and DNA mismatch repair(MMR)expression and pathological characteristics and prognosis quality of colorectal cancer.Methods A total of 226 patients with colorectal cancer admitted to Xuzhou Central Hospital from March 2018 to September 2020 were included.The general data and the preoperative plasma FIB,blood lipid and MMR expression in tumor tissues and adjacent tissues of patients with different pathological characteristics and different prognosis quality were compared.Logistic multivariate regression analysis was used to summarize the related factors affecting the pathological characteristics and prognosis quality of patients.Results Logistic multivariate regression analysis showed that the increase of FIB,lipoprotein a[LP(a)]and low-density lipoprotein cholesterol/high-density lipoprotein cholesterol(L/H),MMR of the lesion,the high or low microsatellite instability(MSI)of MMR adjacent to cancer,and the decrease of HDL-C were independent risk factors for TNM staging increase and 3-year death in patients with colorectal cancer.triglyceride(TC),apolipoprotein(ApoA),L/H,MMR of the lesion,high or low MSI of MMR adjacent to cancer,and decrease of HDL-C were independent risk factors for colorectal cancer(P<0.05).Conclusion The difference of plasma FIB,blood lipid level and MMR expression before operation are closely related to TNM staging,lesion location and prognosis quality of colorectal cancer patients.
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